It's time to get real about medical coding! AI and automation are coming to rescue US all from the labyrinth of codes and modifiers. But first, a joke: What did the physician say to the patient who was asking about the difference between a code and a modifier? "Don't worry, I'll take care of it. It's just a little coding nuance!". Let's dive into how AI will change everything.

What is the Correct Code for Neurology(muscular dystrophy), DMD Gene Sequence Analysis?

This article will explain how to properly code for neurology(muscular dystrophy), DMD gene sequence analysis, including small sequence changes, deletions, duplications, and variants in non-uniquely mappable regions, blood or saliva, identification and characterization of genetic variants. This analysis uses the CPT code 0218U. You should understand this article is just an example, however. CPT codes are proprietary and are owned and licensed by the American Medical Association. To learn the latest, correct CPT codes, you MUST obtain a license and download the CPT codes directly from the American Medical Association! You are required by US law to pay for your license from the American Medical Association and if you are not properly licensed and use current CPT codes you may be subject to fines, penalties and even jail time.

What is 0218U?

CPT code 0218U describes a proprietary laboratory analysis known as Genomic Unity DMD Analysis by Variantyx, Inc. This test helps with the diagnosis of a muscular dystrophy known as Duchenne Muscular Dystrophy or DMD. The procedure consists of examining the genetic code of the patient, often obtained via a blood or saliva sample. The DMD gene is identified, analyzed, and screened for any duplications, deletions or mutations that could indicate a condition known as DMD or BMD. In other words, the lab attempts to "sequence" the DMD gene, looking for any differences in a normal person's DNA.

Modifier 33 Preventive Services

What do we do when someone wants to do this test for purely preventative reasons? A young adult or teenager, for instance, may feel nervous about possible DMD given it runs in the family. Since there is a family history of DMD, they decide to have this genetic analysis performed, even though they have no symptoms. In this case, when the physician orders the 0218U procedure, you must make sure you append the correct modifier to code this preventative lab analysis correctly. The proper modifier to append to 0218U for preventative genetic testing for DMD is Modifier 33. Modifier 33 is known as Preventive Services.

How Modifier 33 is Used In A Medical Billing Story.

"Dr. Jones, why am I taking this blood test, Mom?"

"Your Uncle Ben, has DMD, and there is a family history. So Dr. Jones just wants to know if your genes are normal, that's all, sweety".

The teenager comes in to see Dr. Jones for their appointment. Dr. Jones will likely ask the patient and mother about the family history and symptoms. He has looked over the paperwork submitted by the patient and mother, as well as the results from his review of the teenager's chart, and makes the decision that this is preventative testing. Dr. Jones orders a code 0218U with a modifier 33, because the teenager has no symptoms and wants to simply check for DMD.

Modifier 77 Repeat Procedure by Another Physician

Let's say a physician is treating a new patient. This patient comes to see the new physician because the last doctor recommended a follow-up with a specialist. The patient tells the doctor they already had the test performed and has the report. The patient gives the report to the doctor and the doctor requests to view the results and confirm it matches with their diagnosis, or confirm if additional lab testing may be needed.

In this case, the physician may want to review the original genetic analysis for DMD or to look over the report to confirm it. The modifier that we must append to this 0218U CPT code is 77 - Repeat Procedure by Another Physician or Other Qualified Healthcare Professional.

Modifier 77 - Repeat Procedure By Another Physician - Medical Billing Story

A man who lives in Chicago and has been diagnosed with BMD travels to Houston, Texas, to see a new specialist. The new physician requests the lab analysis results and a review of the analysis report. The physician tells their patient to bring in the results from the previous laboratory test they had done, to give them to the new physician and for the physician to look them over.

The patient will obtain a report from the previous laboratory and deliver it to the new specialist.

In this instance, we must append modifier 77 to code 0218U. Modifier 77 is applied when a physician needs to repeat a previous lab procedure to verify, or obtain information about it. The previous specialist who conducted the lab tests did so, but this new doctor is wanting to perform the repeat laboratory work or to verify and review the previous tests, even though no physical new procedure is performed by the physician.

Modifier 90 Reference (Outside) Laboratory

Modifier 90 is commonly referred to as a "Reference Laboratory." What does that mean? It means the procedure is being sent to another laboratory to be performed and completed.

If Dr. Jones, our physician from the previous story, ordered the test from a different facility instead of the laboratory connected to the office, modifier 90 would need to be used! The code will then become 0218U -90. We should code this with modifier 90 if the provider does not actually do the analysis.

Modifier 90 - Reference (Outside) Laboratory - Medical Billing Story

This patient is very nervous and feels more comfortable getting this analysis done at a "national lab." Dr. Jones reviews this request. It turns out that this national lab does not have an agreement with the patient's insurance. Instead, they bill a different code to the lab.

We must use modifier 90 for all 0218U tests performed by another (reference) lab.

Modifier 91 Repeat Clinical Diagnostic Laboratory Test

Modifier 91 is useful when you repeat a previously performed laboratory test at the patient's request, as long as it is the SAME procedure performed at a previous time. Modifier 91 cannot be used if the lab test has changed and you need a repeat because of the new test or because the original test was incorrect and needs a re-do.

Modifier 91 - Repeat Clinical Diagnostic Laboratory Test - Medical Billing Story

"Dr. Jones, I am still concerned. I have lost 10 pounds in the last two months, Can I please repeat that blood test? I feel much weaker than I did in the last month. Can I have that lab test performed again?

Dr. Jones orders the 0218U analysis, knowing it's a re-test because the previous results were normal, but the patient is now exhibiting a loss of weight. The patient has the lab test repeated and it's the exact same procedure at the exact same location. Dr. Jones would attach Modifier 91 to the code. This is called a "repeat test" and modifier 91 will indicate it to the payers.

Modifier 92 Alternative Laboratory Platform Testing

Modifier 92 is the proper modifier to append to a code when using a different lab platform or technique compared to the previous laboratory analysis, for instance, if a lab test needs to be done again with different equipment, the different technique, the different lab platform, or there was an error that needs a repeat and it will be re-run with a new technique.

Modifier 92 - Alternative Laboratory Platform Testing - Medical Billing Story

The patient's genetic material could be a difficult sample to obtain from their saliva sample. Dr. Jones requests that the laboratory repeat the analysis using a different testing platform to provide the best possible results from the material provided.

If we were coding this we would use modifier 92 - alternative platform for this 0218U CPT code. It is being repeated by the laboratory for a technical reason that was requested by Dr. Jones to guarantee more accuracy.

Modifier ET Emergency Services

Modifier ET is used for emergency medical services when the lab tests are required due to an emergency situation. Imagine our patient was suddenly admitted to the Emergency Room (ER) and they also happen to have a family history of DMD.

Modifier ET - Emergency Services - Medical Billing Story

The patient is sent to the ER after collapsing in the local supermarket. The Emergency Department physicians were concerned because the patient had difficulty breathing and reported difficulty in movement. After speaking with the patient's family, they determine there is a history of BMD.

We would append Modifier ET to the code 0218U if we are reporting on this test conducted in the emergency room due to this emergent condition of the patient, needing to get immediate information and analysis for possible diagnosis of DMD.

Modifier Q0 Investigational Clinical Service in a Clinical Research Study

Modifier Q0 is used when the laboratory service is an "investigational" procedure part of a clinical study. For instance, this test 0218U could be used to validate a new lab technique and thus part of a clinical study or research. This is different from just regular clinical testing! It means it is for the purpose of scientific research.

Modifier Q0 - Investigational Clinical Service in a Clinical Research Study - Medical Billing Story

The local university hospital is currently conducting a clinical trial that uses the Variantyx test on a larger cohort of individuals for research. The objective is to obtain a broader understanding of the gene expression in people with family history of Duchenne Muscular Dystrophy. They use modifier Q0 for 0218U because they are a clinical trial site with their research project.

Modifier Q1 Routine Clinical Service in a Clinical Research Study

The same lab test (0218U), the Genomic Unity DMD Analysis from Variantyx, Inc., could be a standard test for their clinical study, so it's part of a clinical trial but they are not looking for a specific result or information to be tested! This is called a routine lab analysis. This test may also be ordered routinely for subjects in this research. For instance, we may find that every patient at a clinical trial needs to have their gene sequencing performed for this study for another condition, which is part of the routine clinical process in their research. The hospital may also perform the same analysis and bill modifier Q1 for code 0218U.

Modifier Q1 - Routine Clinical Service in a Clinical Research Study - Medical Billing Story

We have an established, large clinical trial and a cohort of patients are undergoing a clinical study that involves receiving medications, new treatments and clinical data collected regularly. This study needs to be performed in multiple hospitals across the nation, as well as for any participant who enters the trial at any of the sites.

The study may call for testing that includes blood analysis such as this 0218U - Genomic Unity DMD Analysis from Variantyx, Inc. The researchers decide to use code 0218U - Q1, to represent a routine clinical service, done for every subject enrolled.

Modifier SC Medically Necessary Service or Supply

In many instances, medical coding, and especially coding in the specialties of laboratory and pathology can require the addition of modifier SC. This is generally considered as a "safety net." Modifier SC, meaning that the service was medically necessary and also indicated for medical reason and should be paid.

Modifier SC - Medically Necessary Service or Supply - Medical Billing Story

The patient in question had difficulty speaking and his movement was slow and labored. The doctor's physical examination showed multiple areas of muscle weakness. The doctor felt that 0218U would give more information as to how best to treat the patient.

Dr. Jones, our physician, may want to append modifier SC, in case the insurer decides that there was not a medical reason or that the procedure wasn't needed. This way, you've demonstrated a "medical necessity" or the justification to perform this test.

Medical coding can be complex. If you are unclear on what modifier should be used in the billing process for the laboratory service that was conducted, review and obtain your current copy of CPT codes from the AMA directly! Make sure you have a current license. This is mandatory and failure to comply will have serious legal consequences and repercussions.

Learn how to code for neurology (muscular dystrophy) DMD gene sequence analysis using CPT code 0218U. This article covers various modifiers like 33 (Preventive Services), 77 (Repeat Procedure), 90 (Reference Lab), 91 (Repeat Test), 92 (Alternative Platform), ET (Emergency), Q0 (Investigational), Q1 (Routine), and SC (Medically Necessary). Discover the right modifier for different clinical scenarios and ensure accurate AI-driven medical coding for this test!

What CPT Modifiers Should I Use for Neurology (Muscular Dystrophy) DMD Gene Sequence Analysis (Code 0218U)?